Trazodone: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
As with most drugs, some people can have an allergic reaction after taking trazodone. This was a rare side effect https://sober-home.org/ in clinical trials of this drug. Most of these side effects may go away within a few days to a couple of weeks.
Trazodone may interact with other medications
Trazodone may cause a sudden drop in blood pressure when standing up from a seated or lying position. To help prevent this, be careful not to get up too quickly. If you feel dizzy, sit or lie down right away until the dizziness stops, then take your time getting up again. Tell your healthcare provider right away if you have any of the following symptoms of orthostatic hypotension. Below is a list of medications that can interact with trazodone.
Is trazodone a controlled substance?
For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Drug-condition interactions can also cause certain effects. For information about these interactions, see the “Trazodone oral tablet precautions” section below. Trazodone is FDA-approved to treat major depressive disorder (MDD) in adults.
Pharmacotherapy for Co-Occurring Alcohol Use Disorder and Post-Traumatic Stress Disorder
These include kidney or liver problems, such as kidney failure or liver failure. These conditions could increase an older adult’s risk of side effects from trazodone. If you have severe or long-lasting symptoms of depression, your doctor may recommend that you receive treatment in a hospital or depression treatment center. When the drug is prescribed in a treatment facility, the maximum recommended dose is 600 mg per day.
These include priapism in males and clitorism in females. Priapism refers to a painful, prolonged erection of the penis. Clitorism describes a painful, prolonged erection of the clitoris. Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if trazodone is right for you. People taking trazodone or other antidepressants may have an increased risk of bleeding or bruising.
However, trazodone is not approved for use in people under the age of 18 years. It’s recommended to avoid drinking alcohol https://sober-home.org/how-does-increased-alcohol-tolerance-affect-a/ while taking this drug. This is because alcohol can worsen sleepiness or dizziness as side effects of trazodone.
According to the Toxic Exposure Surveillance System in the USA, in 2002, there were 93 people who died from this rare adverse effect. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Trazodone only for the indication prescribed. Trazodone can cause painful, long lasting erections in males. In some cases emergency and/or surgical treatment has been required and, in some of these cases, permanent damage has occurred. Before approving coverage for trazodone, your insurance company may require you to get prior authorization.
If you think you may have a medical emergency, immediately call your physician or dial 911. Trazodone is mainly processed or metabolized by enzymes in the liver. Some cases of liver injury or other liver problems have been reported in people taking trazodone, usually after several months of treatment. In rare cases, complete liver failure has occurred after taking trazodone. Alcohol is also known to cause liver problems, especially in people who drink heavily long-term.
This means that both of these drugs increase the level of the neurotransmitter serotonin to prevent depression. Taking Trazodone and alcohol together may increase the risk for physical dependence, drug addiction, and abuse. Moreover, understand that there is no safe amount of alcohol to consume with Desyrel, and with higher doses of the drug, there is an even greater risk of side-effects. For this reason, it is generally not advised to mix Trazodone with alcohol at all.
Trazodone can interact with several other medications and certain supplements. With depression, you have intense and long-lasting feelings of sadness, loss of joy, or emptiness. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect.
Thus, medication adherence and study retention may improve due to a once-daily dosing schedule of doxazosin compared with multiple prazosin doses throughout the day. Human laboratory studies provide an efficient, cost-effective avenue for evaluating the effects of potential medications on psychiatric disorders. Also, researchers can use human laboratory paradigms to screen these potential medications in an effort to optimize the clinical utility of pharmacotherapeutic treatments for comorbid AUD and PTSD. If you’re thinking about combining trazodone with alcohol, you’ll want to understand the risks involved. Both substances are central nervous system depressants, which means they can significantly reduce brain activity.
- For example, half of the studies examining pharmacotherapy for co-occurring AUD and PTSD reviewed in this article investigated treatment effects in veterans, and many of them had combat-related trauma.
- It’s FDA-approved to treat major depressive disorder (MDD) in adults.
- In this medication, drug-drug Trazodone interactions are also possible.
- Trazodone should not be used in patients with a history of heart disease or a recent heart attack.
We are dedicated to creating individualized care for each person who walks through our doors and provide them with the tools they need to make healthy and lasting change. Reach out to us today by calling us or scheduling a conversation at a time that works for you. Alcohol and trazodone are both considered CNS (central nervous system) depressants, and combining them enhances these CNS effects.
Our writers and reviewers are experienced professionals in medicine, addiction treatment, and healthcare. AddictionResource fact-checks all the information before publishing and uses only credible and trusted sources when citing any medical data. Furthermore, this interaction is considered moderate but relatively safe when taken with caution, such as when the dosage instructions of the doctor are diligently followed. According to the study of medical professionals from Italy, taking Desyrel and Gabapentin together may produce synergistic effects for neuropathic pain. Avoid drinking alcohol or taking illegal or recreational drugs while taking trazodone. If any of the following medical conditions or other health factors pertain to you, be sure to talk with your doctor before taking trazodone.
Trazodone may pass into breast milk and may cause side effects in a child who is breastfed. You may need to decide whether to stop breastfeeding or stop taking this medication. Don’t take this drug again if you’ve ever had an allergic reaction to it. Typically, your doctor will start you on a low dosage and adjust it over time to reach the dosage that’s right for you.
For some teenagers and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed or have thoughts about hurting yourself or others. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family have bipolar disorder (manic-depressive disorder) or have tried to commit suicide.
Trazodone may cause allergic reactions, which can be serious. Stop using trazodone and get help right away if you have any of the following symptoms of a serious allergic reaction. While less common, the most serious side effects of trazodone are described below, along with what to do if they happen.
It’s not known for certain whether trazodone is safe or effective for children. Keep in mind that trazodone may be used off-label for sleep. Trazodone is not approved to be used for anxiety or bipolar disorder. It’s only approved to treat major depressive disorder (MDD), which is also called depression. For example, trazodone may be used off-label for anxiety or insomnia.
